Cancer Cell Line Encyclopedia Proteomics

Ccle cancer cell line encyclopedia cclf cancer cell line factory drug repurposing hub prism.

Cancer cell line encyclopedia proteomics. The cancer cell line encyclopedia ccle is an effort to generate large scale profiling datasets across nearly 1 000 cell lines from diverse tissue lineages. Cancer cell lines are important model systems to study normal and aberrant cellular processes. Its original release included gene expression dna copy numbers and hybrid capture sequencing barretina et al 2012. Mass spectrometry based proteomics data is broadly unfamiliar to most biologists in our experience resulting in questions from analysts about how to use the data.

2020 the broad institute of mit harvard. Proteins are essential agents of biological processes. The cancer cell line encyclopedia ccle is an effort to generate large scale profiling datasets across nearly 1 000 cell lines from diverse tissue lineages. Abstract we recently reported the quantitative proteomics of 375 samples as part of the cancer cell line encyclopedia nusinow et al 2020.

Quantitative proteomics of the cancer cell line encyclopedia. To date large scale profiling of cell line collections including the cancer cell line encyclopedia ccle has focused primarily on genetic information whereas deep interrogation of the proteome has remained out of reach. The average per protein correlation between the proteomics data and rnaseq data was 0 5. Abstract we recently reported the quantitative proteomics of 375 samples as part of the cancer cell line encyclopedia nusinow et al 2020.

Quantitative proteomics of the cancer cell line encyclopedia overview. Mass spectrometry based proteomics data is broadly unfamiliar to most biologists in our experience resulting in questions from analysts about how to use the data. The cancer cell line encyclopedia ccle is a catalog of nearly 1 000 human cancer cell lines that have been extensively profiled. In this publication we expand the cancer cell line encyclopedia to include quantitative proteome profiling by.

Gene sets with. Proteins are essential agents of biological processes. To date large scale profiling of cell line collections including the cancer cell line encyclopedia ccle has focused primarily on genetic information whereas deep interrogation of the proteome has remained out of reach. Over the past decade data from gene expression histone profiling.