Cancer Cell Line Encyclopedia Nature

2012 the cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity.

Cancer cell line encyclopedia nature. When coupled with pharmacological profiles for 24 anticancer drugs across 479 of the cell lines this collection allowed identification of genetic lineage and gene expression based predictors of drug sensitivity. A compilation of gene expression chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines. Abstract large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti cancer drug response. 2020 the broad institute of mit harvard.

Nature 528 84 87 2015. Its original release included gene expression dna copy numbers and hybrid capture sequencing. The cancer cell line encyclopedia is a database of gene expression genotype and drug sensitivity data for human cancer cell lines. The ccle cancer cell line encyclopedia project is a collaboration between the broad institute and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer.

Pharmacogenomic agreement between two cancer cell line data sets. Here we describe the cancer cell line encyclopedia ccle. Cancer cell lines are important model systems to study normal and aberrant cellular processes. Here we describe the cancer cell line encyclopedia ccle.

Citation s barretina j et al. To further understand the metabolic diversity of cancer we profiled 225 metabolites in 928 cell lines from more than 20 cancer types in the cancer cell line encyclopedia ccle using liquid. A compilation of gene expression chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines.